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hip pain after covid vaccine pfizer

What you can do after youve had the vaccine, nationalarchives.gov.uk/doc/open-government-licence/version/3, having a painful, heavy feeling and tenderness in the arm where you had your injection, a new, severe headache which is not helped by usual painkillers or is getting worse, an unusual headache which seems worse when lying down or bending over or may be accompanied by, new, unexplained pinprick bruising or bleeding, shortness of breath, chest pain, leg swelling or persistent abdominal pain, feelings of having a fast-beating, fluttering, or pounding heart. I would recommend waiting until someone experiences side effects of fever or pain that require fever-reducing or pain-reducing medications, she said, and not to take them as a prophylaxis to prevent vaccine related symptoms.. I never had back/hip pain. Some patients may experience side effects after vaccination, but these are typically mild and go away in a few days. Dr. David J. Cennimo, an infectious disease physician and assistant professor at Rutgers New Jersey Medical School, said these are signs of an appropriate recognition and immune reaction to the vaccine.. There are ways to manage pain that you may have after coronavirus (COVID-19). CoronaVac vaccine; adverse event; reactive arthritis. This leaflet tells you what to expect after you have had your primary or booster vaccination. But catching coronavirus is more risky for your health which is why doctors recommend people get immunised. No genitourinary symptoms which could have suggested a urinary tract infection were reported. J Orthop Case Rep. 2021 Mar;11(3):79-84. doi: 10.13107/jocr.2021.v11.i03.2098. Express. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Pain, swelling or bruising after intense or repetitive exercise. Seek treatment right away if you develop a rash, difficulty breathing, or chest or abdominal pain. plan the things you need to do each day to help you keep on top of your pain pace yourself - if your pain is stopping you completing a task you can try again later try to relax - this can be hard, but finding something which relaxes you will reduce the stress . "But there is overwhelming evidence of the effectiveness of the vaccine against serious illness. That's why we need large studies of real-world data, like this one, which looked at the healthcare records of millions of people. Reactive arthritis after SARS-CoV-2 infection. Very common side effects in the first day or two include: having a painful, heavy feeling and tenderness in the arm where you had your injection feeling tired headache, aches and chills You may. You can take painkillers such as paracetamol if you need to. READ MORE:Pfizer vaccine: Four 'troubling' side effects that mainly follow second dose of Covid jab, "Pfizer-BioNTech COVID-19 Vaccine is still being studied in clinical trials.". Stay at home and get a test. This publication is available at https://www.gov.uk/government/publications/covid-19-vaccination-what-to-expect-after-vaccination/what-to-expect-after-your-covid-19-vaccination. Herein, we report a 58 year old woman hospitalized following COVID-19 infection and was discharged after a week. The Food and Drug Administrations independent vaccine advisory committee voted unanimously in favor of having all COVID-19 vaccines in the United, You may wonder whether supplementing with vitamin D can help reduce your risk of contracting the new coronavirus that causes COVID-19. RMD Open. Common reactions include: Swelling or redness at the site of the injection Systemic reactions, such as fever, chills, nausea, vomiting, muscle aches, or fatigue PMC The report added that the reactions to the vaccines could be moderate in intensity, but resolved within a few days after vaccination. | Audio "I also work as a GP and we want to make sure people are taking up the vaccine and booster jabs, and by doing that we will protect the health of the nation in the best way we can.". DON'T MISSType 2 diabetes: 'Foot drop' is warning sign[INSIGHT]Vitamin B12 deficiency: Irreversible signs[ADVICE]Pancreatic cancer: Indigestion is a sign[TIPS]. Provided by the Springer Nature SharedIt content-sharing initiative. Article One night I had the chills. name, location or any personal health conditions. Digestive symptoms, like stomach pain, might be among the earliest symptoms of COVID-19 that you experience. Would you like email updates of new search results? Article More often after the second dose 8600 Rockville Pike As for the daily number of people testing positive for the virus, this stands at 6,573 people for the same time period. https://doi.org/10.1016/j.jaad.2008.02.047. Case series of acute arthritis during COVID-19 admission. I would think your issues may be from something else. MM, KS, and SM planned and carried out the laboratory tests. You can unsubscribe at any time. The https:// ensures that you are connecting to the When reported, the cases have especially been in adolescents and young adult males within several days after mRNA COVID-19 vaccination (Pfizer-BioNTech or Moderna). Like all medicines, no vaccine is completely effective, so you should continue to take recommended precautions to avoid infection. VideoRussian minister laughed at for Ukraine war claims, The children left behind in Cuba's mass exodus, Xi Jinping's power grab - and why it matters, Snow, Fire and Lights: Photos of the Week. 2022 Jul 9;14(7):e26702. Coronaviruses. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. It will help to reduce the risk of you passing on the virus. British Sign Language (BSL) Jen Mills Wednesday 7 Apr 2021 10:47 pm. Corona Virus Disease-19 Vaccine-associated Autoimmune Disorders. The preclinical evaluation of Covid vaccine AZ (study 514559) evidenced vaccine distribution) to various body tissues beyond injection site including sciatic nerves [4]. -, Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. MRI revealed a fluid rim around the pelvic area, suggesting inflammation in the right hip. Two other reactive arthritis cases following infection with SARS-COV-2 were reported, one of a 57years old man in Japan and the other of a 73years old man in Turkey [14, 15]. COVID-19 can affect and even shrink certain parts of your brain. Staff giving the vaccine are trained to deal with allergic reactions and treat them immediately. A few days ago, the lower back and hip pain started up again. An increase in thickness is, MRI of the pelvis. Published on Thursday, March 4, the weekly summary of Yellow Card reporting produced by government openly stated: "Side effects need to be continuously balanced against the expected benefits in preventing illness." Ten days after her discharge, she represented to the clinic complaining of radiating pain in her right hip, which had caused her walking difficulties. Manage cookies/Do not sell my data we use in the preference centre. Pfizer Says Bivalent COVID-19 Booster Significantly Increases Antibodies to Fight Omicron. SARS-COV-2 usually presents with respiratory symptoms but can have various other manifestations and sequelae. Pathogenesis of ankylosing spondylitis and reactive arthritis. 2022 Oct 10;9:933914. doi: 10.3389/fmed.2022.933914. Background: Keywords: Case presentation: Metyas S, Chen C, Aung T, Ballester A, Cheav S. Curr Rheumatol Rev. Experience of a tertiary care centre with a review of the literature. Over 45 years of age, pain worse when walking and stiffness after moving. Please enable it to take advantage of the complete set of features! Why Alex Murdaugh was spared the death penalty, Why Trudeau is facing calls for a public inquiry, The shocking legacy of the Dutch 'Hunger Winter'. Are there other more serious side effects? They could be covid symptoms. If your pain in your lower back and left hip s not resolving it may be a sign of a problem. 2022 Sep-Oct;42(5):1415-1432. doi: 10.1148/rg.220036. This information may be updated, if necessary. Schools are set to return on Monday, March 8, and lots of people will be keeping their eyes on the figures. Find recent orders, do a return or exchange, create a Wish List & more. You get any of these symptoms starting from around 4 days to 4 weeks after being vaccinated: There have been rare cases of inflammation of the heart (myocarditis) reported after COVID-19 vaccination. It can also prevent you from having the long-lasting health problems experienced by some COVID-19 patients, or COVID-19 long haulers.. It lasted one day. Since reactive arthritis typically happens due to an infection, the patient was tested for Brucellosis (Using Wright, Combs Wright, and 2ME tests) and Tuberculosis (Using PPD skin test) as two of the primary organisms causing ReA. After that, El Sahly says, "the vaccine will no longer be stable, and its biologic effect will . If your arm is particularly sore, you may find heavy lifting difficult. But these records on their own cannot tell us whether they were caused by the jab. She showed dramatic improvement starting 5days after her visit and reached remission after 14days. Back to I had neck and lower back pain as well as a headache. Ancet. But COVID-19 vaccine studies that have already been done suggest that taking a pain reliever after injection, if needed, may not cause that much of a problem. 2 from Pfizer or Moderna, many people feel an all-over malaise, with chills, potential for fever, and body aches. PubMed Central This article. The EMA did not give details on Wednesday on how many cases of these conditions were recorded, but said it had requested more data from the companies. Most people with allergies (including food or penicillin allergies) can be vaccinated against COVID-19. Clipboard, Search History, and several other advanced features are temporarily unavailable. Most pain should eventually go away, but sometimes it might carry on for longer. Herein, we report a 58year old woman hospitalized following COVID-19 infection and was discharged after a week. MeSH Cite this article. | Easy Read. These are erythema multiforme, a form of allergic skin reaction; glomerulonephritis or kidney inflammation; and nephrotic syndrome, a renal disorder characterised by heavy urinary protein losses. 2022 Oct 20;3(3):111-119. doi: 10.2478/rir-2022-0019. https://doi.org/10.1097/00000441-200608000-00008. Rachel Schraer, BBC health disinformation reporter, Russian minister laughed at for Ukraine war claims. *You're signing up to receive QVC promotional email. She has lung and kidney damage (only one kidney left) as a result of extensive . Wu Z, Hu Y, Xu M, Chen Z, Yang W, Jiang Z, Li M, Jin H, Cui G, Chen P, Wang L, Zhao G, Ding Y, Zhao Y, Yin W. Lancet Infect Dis. The Delta variant is raging in many parts of the world and unvaccinated populations are at a far greater risk of death and the long-term effects associated with the viral disease. They say it remains unclear why these links appear and suggest more studies are needed to understand this. Because of the high risk of complications and death from COVID-19, the Medicines and Healthcare products Regulatory Agency (MHRA), the World Health Organization and the European Medicines Agency have concluded that the balance is very much in favour of vaccination. Read about our approach to external linking. -, Wu IB, Schwartz RA. This study was approved and supervised by the Research and Ethics Committee of Qom University of Medical Sciences and Health Services. COVID-19-associated arthritis: an emerging new entity? Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Further attentions should be put to determine which individual is at higher risk for developing autoimmune diseases after COVID-19 vaccination. Reverse Transcription Polymerase Chain Reaction, Mean Corpuscular Hemoglobin Concentration, Serum Glutamic-Oxaloacetic Transaminase (Aspartate aminotransferase), Serum Glutamic-Pyruvic Transaminase (Alanine transaminase). Google Scholar. Saturday, 4th March 2023See today's front and back pages, download the newspaper, order back issues and use the historic Daily Express newspaper archive. All of the authors have no funding sources to declare relevant to this report. Product information on COVID-19 vaccines and medicines is available on this page. COVID-19 vaccines can also cause temporary side effects that feel similar to those of arthritis or RA, such as: joint pain muscle aches fever fatigue These effects usually last a few days but. Case Report of a Rare Cause of Reactive Arthritis: Leptospirosis. One of the rare complications of COVID-19 infection is Reactive Arthritis. Int J Antimicrob Agents. Enteric infections were also symptomatically ruled out. Am J Med Sci. Infect Dis Clin N Am. The number of coronavirus vaccinations in the UK is now nearing 21 million. Before Are You Fully Vaccinated Against COVID-19? This case report was prepared following the CARE Guidelines [7]. Article One CDC study found that adults who received the J&J/Janssen COVID-19 . 1995-2023 QVC, Inc. All rights reserved. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. SARS-COV-2 infection was previously thought to only display respiratory symptoms as part of the coronaviridae family [3, 4]; The rapid spread of this virus, however, revealed various sequelae and symptoms, with the autoimmune system having a prominent role in most of these reactions [5, 6]. Learn about causes, treatment, and. Chills. Kim TH, Uhm WS, Inman RD. She was started on interferon 1, dexamethasone, ceftriaxone, enoxaparin, and nortriptyline and was discharged after 5days with oxygen levels of 92%. Online ahead of print. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). 2021 Feb;21(2):181-192. doi: 10.1016/S1473-3099(20)30843-4. It may take a few weeks from the first dose for your body to build up protection. Yes, you can take OTC pain meds after getting the Covid vaccine, says CDC plus other tips for dealing with side effects. Some people are not able to take either acetaminophen or ibuprofen due to other underlying health conditions, she said. Acute transverse myelitis after inactivated COVID-19 vaccine. With less inflammation, he said, there may also be a lower immune response to the vaccine. Google Scholar. Adverse reactions were less frequent in older adults, aged 55 and older predominately affecting younger people instead. Careers. Can you go back to daily activities after having your vaccine? The patient was started on 100mg indomethacin twice a day and 80mg IM depot prednisolone based on this diagnosis. For fever, drink plenty of fluids, wear light pajamas or clothing, sponge your body with lukewarm (not cold) water, and eat popsicles. This is a case report of a 68-year-old woman without history of autoimmune conditions, who presented to our emergency department 7 days after receiving the Pfizer-BioNTech COVID-19 vaccine. Learn how it feels and how to manage it. Cennimo said the pre-COVID-19 vaccine research in children found that taking a fever-reducing drug only affected the production of antibodies if the drug was taken before the injection. 2021 Jun;21(6):803-812. doi: 10.1016/S1473-3099(20)30987-7. 2023 Feb;26(2):267-277. doi: 10.1111/1756-185X.14482. Unauthorized use of these marks is strictly prohibited. HHS Vulnerability Disclosure, Help 2022 Sep;8(2):e002519. | Although a fever can occur within a day or two of vaccination, if you have any other COVID-19 symptoms or your fever lasts longer, stay at home and arrange to have a test. After ultrasound and MRI, she was diagnosed with reactive arthritis inflammation in the hip's neck. For most people, however, the . Who can get a COVID-19 vaccine Everyone aged 5 (on or before 31 August 2022) and over can get a 1st and 2nd dose of the COVID-19 vaccine. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. You can unsubscribe at any time. The approved COVID-19 vaccines have been tested on thousands of people in the UK and around the world, including: All vaccines used in the UK must be approved by the independent Medicines and Healthcare products Regulatory Agency (MHRA). J Clin Epidemiol. MM conceived and planned the visit. Int J Rheum Dis. trump white house censored head of its own coronavirus task force, new . MM, TE and RS carried out the physical examinations. Accessibility 2019;32(7):258. doi: 10.7759/cureus.26702. Color doppler sonography of right lower extremities found no signs of either stenosis in the arteries and thrombosis in deep and superficial veins. 2020;10(1136):annrheumdis--2020--217914. Bethesda, MD 20894, Web Policies Can you catch COVID-19 from the vaccines? She presented with swollen, painful left knee joint for 18 d. She had been inoculated 0.5 ml CoronaVac vaccine on 0 d and the 14th day with deltoid intramuscular injection. This may include adverts from us and 3rd parties based on our understanding. Tropical Diseases, Travel Medicine and Vaccines Coronaviruses. Coronavirus (COVID-19) vaccination. | However, for some people the side effects make them feel like they have the flu, or affect their ability to perform daily activities. Alarm bells only start to ring if a complication is seen more often than might expected in a population. 2022;18(4):346-351. doi: 10.2174/1573397118666220211155716. The https:// ensures that you are connecting to the eCollection 2022 Jul. We use some essential cookies to make this website work. Its possible to develop shingles after COVID-19 vaccination or after having COVID-19, but cases are rare. The frequency and severity of systemic adverse events was higher after dose 2 than dose 1. Learn how this happens and if you can prevent it. INACTIVATED COVID-19 VACCINE CAN INDUCE REACTIVE POLYARTHRITIS IN OLDER PATIENTS: REPORT OF TWO CASES. These cases have been seen mostly in younger men within several days after vaccination. All of the authors have no conflict of interest to declare. These microorganisms, however, are not the only ones to which ReA can be attributed. Wiley; 2016. p. 124365. Each of these side effects were reported in more than one in 10 people involved in the trial. The MHRA makes sure the vaccines meet strict international standards for safety, quality and effectiveness. Further attention should be paid to symptoms occurring after an episode of infection with COVID-19 to expand our understanding of the disease and the symptoms with which it can manifest. government site. Keywords: 2020 Nov 28;12(11):e11761. Some information may be out of date. Video, Russian minister laughed at for Ukraine war claims, US-made cheese can be called 'gruyere' - court, AOC under investigation for Met Gala dress, The children left behind in Cuba's exodus, Saving Private Ryan actor Tom Sizemore dies at 61, Alex Murdaugh's legal troubles are far from over, Nelson's 97th-minute stunner gives Arsenal victory, Sonic boom heard as RAF Typhoon jets escort plane, Walkie Talkie architect Rafael Violy dies aged 78. And of course, rest. fauci says new surge in covid-19 cases has three main causes. The protocols for the late-stage clinical trials of the Pfizer-BioNTech and Moderna-NIAID coronavirus vaccines didnt prevent people from taking pain-relieving medications if they felt they needed it. Ono K, Kishimoto M, Shimasaki T, Uchida H, Kurai D, Deshpande GA, et al. You should be able to resume activities that are normal for you as long as you feel well. Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. A summary of her laboratory results and her vital information is available in Table1. Researchers hope to expand their study to consider second vaccine doses and booster doses. COVID-19 Vaccine: Key FDA Panel Supports Updated Annual Shots. Ultrasonic images of soft tissue around the hip. doi: 10.1016/j.berh.2004.05.008. Pal A, Roongta R, Mondal S, Sinha D, Sinhamahapatra P, Ghosh A, Chattopadhyay A. Reumatol Clin (Engl Ed). sharing sensitive information, make sure youre on a federal 2004;18(5 SPEC. CAS | Click here to toggle the visibility of the search bar. Cennimo said its not known how these medications interfere with vaccines, but the drugs may dampen the inflammatory response which shows up as fever and aches. Reactive arthritis in the right hip following COVID-19 infection: a case report. New COVID-19 boosters could be authorized by the FDA before full data from human trials are in because of past data on similar vaccines. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. In regards to the Oxford-AstraZenenca vaccine, more than 23,000 participants have been involved in the Yellow Card's latest report. "Vaccination is the single most effective way to reduce deaths and severe illness from COVID-19," said the MHRA. J Gen Intern Med. 2020;35(5):15459. 2023 Feb 21:1-3. doi: 10.1007/s00167-023-07332-z. Federal government websites often end in .gov or .mil. I can't even get an appt but I sure hope that's not the case since I have horrible back pain anyway. There were 10 frequently reported reactions to the jab, happening to more than one in 10 people, which included: Injection-site tenderness Injection-site pain Headache Fatigue (feeling tired). For the COVID-19 vaccines Pfizer and Moderna, you have six hours from the time the vial is punctured. You don't have to spend long online to stumble on posts falsely claiming Covid vaccines are causing all kinds of frightening side effects. Here's How to Tell. Draw an inverted triangle below the shoulder tip using identified anatomical markers. He had his second dose of the coronavirus vaccine last week and took ibuprofen afterwards for a low-grade fever and some aches. Peiris JSM. By using this website, you agree to our She is a teacher that got covid and was not as ill as when they gave her shots. Bookshelf National Library of Medicine Can Vitamin D Lower Your Risk of COVID-19? Calabrese LH, Naides SJ. Once a vaccine is approved, it's closely monitored to continue to make sure it is safe and effective. 2). Cheung S, Delgado Fuentes A, Fetterman AD. Springer Nature. Chat to an NHS operator in our Live Chat - opens a new window, your pain is affecting your day to day life, you're worried about possible long COVID symptomsin a child or young person under 18. The coronavirus (COVID-19) vaccines are safe and effective. Side effects of the coronavirus vaccines developed by Pfizer and Moderna are common, and they become more frequent after the second dose. sharing sensitive information, make sure youre on a federal Further investigation is required to establish the probability of ReA after infection with the SARS-COV-2 and to find the most appropriate treatment for this condition. Physical examination revealed a limited range of motion in the right hip due to pain in the right sacroiliac. In the study, following the first dose of vaccine, there were: Meanwhile for people who had a coronavirus infection, there were approximately: There was also an increased risk of bleeds on the brain in the first seven days after a positive Covid test, but risks returned to a normal, baseline level within a month. There are data in the vaccine literature, long predating COVID-19 and almost all [done] in children, that premedication with [fever-reducing drugs] like acetaminophen or ibuprofen decrease the antibody response to the first dose of vaccine, Cennimo said. Awan MH, Samreen S, Salim B, Gul H, Perveen S, Nasim A. Rheumatol Immunol Res. | Like all medicines, vaccines can cause side effects. MRI revealed a fluid rim around the pelvic area,, MeSH Do we miss rare adverse events induced by COVID-19 vaccination. The investigators examined the NHS records of 32 million adults in England to assess any rare adverse events linked to Covid vaccines. For now, the number of people testing positive for coronavirus, and those dying from the disease has been decreasing. 2005-2023 Healthline Media a Red Ventures Company. In: Clinical Virology. Fergus Walsh: What does Covid-19 do to the brain? Peiris JSM. Additionally, MRI revealed a fluid rim around the pelvic area, suggesting inflammation in the right hip and sacroiliitis (Fig. Next review due: 24 April 2023, side effects and safety of the COVID-19 vaccine for children, Moderna (Spikevax) COVID-19 vaccine patient leaflet on GOV.UK, Oxford/AstraZeneca COVID-19 vaccine patient leaflet on GOV.UK, Pfizer/BioNTech COVID-19 vaccine patient leaflet on GOV.UK, a severe headache that is not relieved with painkillers or is getting worse, a headache that feels worse when you lie down or bend over, a headache that's unusual for you along with blurred vision, feeling or being sick, problems speaking, weakness, drowsiness or seizures (fits), a rash that looks like small bruises or bleeding under the skin, shortness of breath, chest pain, leg swelling or persistent abdominal (tummy) pain, a fast-beating, fluttering or pounding heart (palpitations), children and young people aged between 12 and 17. official website and that any information you provide is encrypted The Oxford jab tended to have more mild side effects if you were 65 or older in age. She consequently presented to the clinic ten days after her discharge, complaining of walking difficulties and radiating pain in her right hip. It is over a month after your second dose, so this is not a short term effect or potential problem, related or not to the shot. Autoimmune reactions to viral and bacterial infections are a known phenomenon, occurring 24weeks after infection and affecting joints in the lower extremities [1, 2]. The .gov means its official. | Herein we report a case of reactive arthritis (ReA) after COVID-19 infection. No research has been done to look specifically at whether acetaminophen or ibuprofen can interfere with how well the coronavirus vaccine works. When compared to the values recorded at the time of admission for COVID-19 infection, the CRP and ESR of the patient were found to be increased from 5.7 to 6.5mg/L and from 39 to 45mmol/h, respectively, which indicated an ongoing autoimmune reaction as a result of the infection. If your symptoms seem to get worse or if you are concerned, call NHS 111. However, an itchy throat is more commonly associated with allergies. My summary it's probably from the immunization. Is apple cider vinegar good for your liver? what happens after one dose of pfizer or moderna vaccine? This may include adverts from us and 3rd parties based on our understanding. Faced with a couple of days of flu-like discomfort, many people including physicians will reach for an over-the-counter medication such as ibuprofen (Advil, Motrin) or acetaminophen (Tylenol) to relieve their fever and pain. doi: 10.1016/j.jaad.2008.02.047. This video explains how the COVID-19 vaccines were developed quickly but safely. Do. Epub 2022 Jul 22. Lower back and hip pain after Pfizer vaccines. According to Pfizer's official website, side effects that have been reported with the Pfizer-BioNTech COVID-19 Vaccine include: "These may not be all the possible side effects of the Pfizer-BioNTech COVID-19 Vaccine," notes Pfizer. | Espaol More recently, a study published this month in the Journal of Virology found that nonsteroidal anti-inflammatory drugs (NSAIDs) which include ibuprofen reduced the production of antibodies and other aspects of the immune response to SARS-CoV-2. 2020;55(5):105954. https://doi.org/10.1016/j.ijantimicag.2020.105954. Bethesda, MD 20894, Web Policies Epub 2023 Jan 13. Read about our approach to external linking. The MHRA makes sure the vaccines meet strict international standards for safety, quality and effectiveness. Correspondence to

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hip pain after covid vaccine pfizer